Programme

Registration

Lunch

Welcome addresses

Gaetano Cairo & Sergio Giannattasio

Plenary Lecture

Julián Aragonés (Madrid, Spain)

Metabolic reprogramming through HIF oxygen sensing pathways in disease

SESSION I - Cell Death and Autophagy

Chairs: A. Montecucco & E. O’Brien

Valeria Matranga (Palermo)

Autophagy induction in sea urchin embryos exposed to gadolinium ions

Federica Maccarinelli (Brescia)

Mice lacking mitochondrial ferritin are more sensitive to doxorubicin-mediated cardiotoxicity

Cristina Mazzoni (Rome)

Role of GABA metabolism enzymes during stress, aging and apoptosis in budding yeast, Saccharomyces cerevisiae

Coffee break and Poster viewing

SESSION II - Heat Shock and Protein Misfolding Response (I)

Chairs: M.R. Woodford & V. Matranga

Anna Maria Giuliodori (Camerino)

Fine mapping of the Escherichia coli cold-shock protein CspA binding sites on its own mRNA

Fabiana Geraci (Palermo)

Autocrine role of extracellular Hsp70 in mesoangioblast migration capability

Wei Li (Los Angeles, CA, USA)

The non-Chaperoning function of secreted Heat Shock Protein-90a defines motility and invasiveness of breast cancer cells

Edward O'Brien (Calgary, AB, Canada)

Extracellular HSP27 attenuates atherogenesis by reducing plaque apoptosis and inflammation: insights into a novel signaling pathway for atheroprotection

Poster Session

Business meeting and election of vice-chair

Dinner

Session III: Cell Stress and Cancer

Chairs: W. Li & J. Aragonés

Nicoletta Guaragnella (Bari)

Silencing of the tumor suppressor BRCA2 decreases anoikis and its heterologous expression exacerbates acetic acid-induced programmed cell death in yeast cells

Morena Catillo (Pavia)

Metabolic stress controls alternative splicing programs: relevance to cancer biology

Elia Ranzato (Alessandria)

GRP78 and T-type Ca²⁺ channels: novel EGCG targets against malignant mesothelioma

Session IV: Cell Stress and Genome Instability

Chairs: D. Cavalieri & C. Mazzoni

Valentina Tosato (Trieste)

Post-translocational adaptation (PTA) to cellular stress

Jade Quartararo (Parma)

Mitochondria and lifespan extension in Saccharomyces cerevisiae: the longevity mutations sch9∆ and rei1∆ contribute to mitochondrial DNA stability

Alessandra Montecucco (Pavia)

Chronic DNA damage hampers cell morphology and motility

Manuela Minguzzi (Bologna)

GSK3β inhibition in osteoarthritic human primary chondrocytes determines oxidative stress and DNA damage response leading to a worse disease phenotype

Coffee break and Poster viewing

Session V: Heat Shock and Protein Misfolding Response (II)

Chairs: M.C. Roccheri & A. Poletti

Duccio Cavalieri (San Michele all'Adige)

Epigenetics at work: phenotypic switching by Heat Shock Proteins and prions in yeast

Mark Woodford (Syracuse, NY, USA)

Post-translation modification crosstalk regulates Hsp90 chaperone cycle

Riccardo Cristofani (Milan)

Accumulation of motor neuron diseases associated misfolded proteins is counteracted by dynein inhibition.

Concluding remarks - Winner of the F. Ritossa award announced

Lunch